Hepatic Lipase C-514T Polymorphism - (High Density Lipoprotein Cholesterol)
This effect is also "recessive", meaning that each gene is expressed
independently of the other. Thus a TT genotype would, in general, have
twice as much of an increase of HDL-C as a CT genotype when
compared to a CC genotype.
This genetic influence on hepatic lipase appears to occur only in males.
Environmental factors are also involved. Drugs, such as anabolic
steroids, increase hepatic lipase activity and cause a proportional
reduction in plasma levels.
Cigarette smoking, obesity , and lack of exercise are other environmental
factors that are associated with low HDL-C. However, in these cases, it
has not yet been determined if the effect is via a change in hepatic lipase
or some other metabolic function.
References:
Guerra R, Wang J, Grundy SM, Cohen JC. A hepatic lipase (LIPC) allele
associated with high plasma concentrations of high density lipoprotein
cholesterol. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4532-7.
Kantor MA, Bianchini A, Bernier D, Sady SP, Thompson PD. Androgens
reduce HDL2-cholesterol and increase hepatic triglyceride lipase activity.
Med Sci Sports Exerc. 1985 Aug;17(4):462-5.
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(NCBI).
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